a Record control number WOS:000346407500008

a ISSN 0090-2977

a Original cataloging agency NEU GrandLibrary

a Language code of text/sound track or separate title eng

a Classification number WL355

b Item number .P76 2014

a Personal name Basaranlar, G.

a Title Protective Actions of Ghrelin Global Cerebral Ischemia-Induced Memory Deficits

h Medium Electronic Document

c Statement of responsibility, etc G.Başaranlar, N.Derin, R.Tan, G.Tanrıöver, N.Demir.

b Name of publisher, distributor, etc Sprınger,

c Date of publication, distribution, etc 2014.

a Summary, etc In our study, we investigated transient global cerebral ischemia (TGCI)-induced changes in spatial memory and motor activity together with apoptotic, oxidant, and NO/NOS signaling parameters in rats and the effects of treatment of animals with ghrelin. The TGCI-induced deficiencies of spatial memory and motor activity in the Y-maze and open field tests were attenuated by ghrelin treatment. Furthermore, ghrelin administration lowered the levels of caspase-3 and iNOS elevated by TGCI in the hippocampus. Thus, we conclude that ghrelin exerts a neuroprotective action against hippocampal TGCI injury via influencing apoptotic, oxidant, and/or NO/NOS pathways. If the underlying mechanisms of action of this agent are fully clarified, ghrelin might be a candidate drug for treatment of TGCI-induced memory impairments.

a Topical term or geographic name as entry element Cerebral ischemia

a Topical term or geographic name as entry element Near East University Article

a Topical term or geographic name as entry element Yakın Doğu Üniversitesi Makale

a Main entry heading Neurophysıology

g Relationship information Aug 2014, Vol.46, Issue:4, p.343-351

x International Standard Serial Number 00902977

u Uniform Resource Identifier http://library.neu.edu.tr:2048/login?url=http://dx.doi.org/10.1007/s11062-014-9454-1